Structure of PDB 4jc5 Chain A

Receptor sequence
>4jc5A (length=187) Species: 10090 (Mus musculus) [Search protein sequence]
KLNVAHGLAWSYYIGYLRLILPGLQARIRMFNQLHNNMLSGAGSRRLYIL
FPLDCGVPDNLSVVDPNIRFRDMLPQQNIDRAGIKNRVYSNSVYEILENG
QPAGVCILEYATPLQTLFAMSQDAKAGFSREDRLEQAKLFCRTLEEILED
VPESRNNCRLIVYQEPTDGNSFSLSQEVLRHIRQEEK
3D structure
PDB4jc5 Species-specific detection of the antiviral small-molecule compound CMA by STING.
ChainA
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1K5 A S161 Y162 T262 P263 Q265 T266 S11 Y12 T112 P113 Q115 T116 BindingDB: Kd=3300nM
BS02 1K5 A S161 G165 R237 S11 G15 R87 BindingDB: Kd=3300nM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:4jc5, PDBe:4jc5, PDBj:4jc5
PDBsum4jc5
PubMed23604073
UniProtQ3TBT3|STING_MOUSE Stimulator of interferon genes protein (Gene Name=Sting1)

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