Structure of PDB 4ja7 Chain A

Receptor sequence
>4ja7A (length=466) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GTLKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAY
LRTECYGYALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETV
VKVKPNDKDAKMKYQECSKIVKQKAFERSVVDSLDIESMTIEDEYSGPKL
EDGKVTITFMKDLMQWYKDQKKLHRKCAYQILVQVKEVLCKLSTLVETTL
KETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVE
VILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELF
SEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPM
CDLLWSDPQPQNGRSVSKRGVSCQFGPDVTKAFLEENQLDYIIRSHEVKA
EGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPH
PNVKPMAYANTLLQLG
3D structure
PDB4ja7 Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D242 H244 D271 D274 R275 N303 H304 H352 R400 H427
Catalytic site (residue number reindexed from 1) D211 H213 D240 D243 R244 N272 H273 H321 R369 H396
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D271 N303 H352 H427 D240 N272 H321 H396
BS02 MG A D242 H244 D271 D211 H213 D240
Gene Ontology
Molecular Function
GO:0001965 G-protein alpha-subunit binding
GO:0003723 RNA binding
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0017018 myosin phosphatase activity
GO:0031072 heat shock protein binding
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0044877 protein-containing complex binding
GO:0046872 metal ion binding
GO:0051879 Hsp90 protein binding
Biological Process
GO:0010288 response to lead ion
GO:0043066 negative regulation of apoptotic process
GO:0043278 response to morphine
GO:0070262 peptidyl-serine dephosphorylation
GO:0070301 cellular response to hydrogen peroxide
GO:0071276 cellular response to cadmium ion
GO:1904550 response to arachidonate
GO:2000324 positive regulation of glucocorticoid receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0032991 protein-containing complex
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0101031 protein folding chaperone complex
GO:1990635 proximal dendrite

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4ja7, PDBe:4ja7, PDBj:4ja7
PDBsum4ja7
PubMed26182372
UniProtP53042|PPP5_RAT Serine/threonine-protein phosphatase 5 (Gene Name=Ppp5c)

[Back to BioLiP]