Structure of PDB 4j9s Chain A

Receptor sequence

>4j9sA (length=424) Species: 9606 (Homo sapiens) [Search protein sequence]

HMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIA
VSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEV
MEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEG
LPQGTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIE
RETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKI
RSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGI
EHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKD
RNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKN
CNTSTEWSPPLTMLFLCATKFSAS

3D structure

PDB

4j9s Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.

Chain

Resolution

1.95 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q38 Y39 W42 R61 W64 K86 L89 R93 P316 K317 T318 G320 C321 S322 K323 N324 P326 R351	Q39 Y40 W43 R62 W65 K87 L90 R94 P311 K312 T313 G315 C316 S317 K318 N319 P321 R346
BS02	dna	A	R61 K224 S257 G259 G260 K261 L262 R377 L381 R382	R62 K219 S252 G254 G255 K256 L257 R372 L376 R377

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding

	Biological Process
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4j9s, PDBe:4j9s, PDBj:4j9s
PDBsum	4j9s
PubMed	23630267
UniProt	Q9Y253\|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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