Structure of PDB 4j9r Chain A

Receptor sequence

>4j9rA (length=423) Species: 9606 (Homo sapiens) [Search protein sequence]

TGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSY
EARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEI
MSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLPQ
GEETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIER
ETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIR
SLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIE
HDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDR
NDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNC
NTSTEWSPPLTMLFLCATKFSAS

3D structure

PDB

4j9r Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.

Chain

Resolution

2.35 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q38 Y39 W42 S62 K86 P316 K317 T318 G320 C321 S322 K323 N324 P326 R351	Q36 Y37 W40 S60 K84 P310 K311 T312 G314 C315 S316 K317 N318 P320 R345
BS02	dna	A	S113 D115 E116 K224 S257 G259 G260 K261 L262 R377 R382 C384	S111 D113 E114 K218 S251 G253 G254 K255 L256 R371 R376 C378

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding

	Biological Process
GO:0006281	DNA repair

View graph for
Molecular Function

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Biological Process

External links

PDB	RCSB:4j9r, PDBe:4j9r, PDBj:4j9r
PDBsum	4j9r
PubMed	23630267
UniProt	Q9Y253\|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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