Structure of PDB 4j9q Chain A

Receptor sequence

>4j9qA (length=427) Species: 9606 (Homo sapiens)

TGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSY
EARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEI
MSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLPQ
GPEETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIE
RETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKI
RSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGI
EHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKD
RNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKN
CNTSGIQTEWSPPLTMLFLCATKFSAS

3D structure

• PDB: 4j9q Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.
• Chain: A
• Resolution: 1.96 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q38 Y39 W42 S62 K86 R93 R313 P316 K317 T318 G320 C321 S322 K323 N324 R351	Q36 Y37 W40 S60 K84 R91 R308 P311 K312 T313 G315 C316 S317 K318 N319 R346
BS02	dna	A	F18 I48 A49 R61 D115 K224 S257 G259 G260 K261 L262 R377 L381 R382 C384	F16 I46 A47 R59 D113 K219 S252 G254 G255 K256 L257 R372 L376 R377 C379
BS03	MG	A	D13 D115	D11 D113

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:4j9q, PDBe:4j9q, PDBj:4j9q
• PDBsum: 4j9q
• PubMed: 23630267
• UniProt: Q9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)