Structure of PDB 4j9o Chain A

Receptor sequence

>4j9oA (length=418) Species: 9606 (Homo sapiens)

TGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSY
EARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEI
MSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLPQ
GPTVQKEGMRKQGLFQWLDSLNLTSPDLQLTVGAVIVEEMRAAIERETGF
QCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGG
KLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPV
KPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRNDND
RVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNTSE
WSPPLTMLFLCATKFSAS

3D structure

• PDB: 4j9o Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.
• Chain: A
• Resolution: 2.597 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q38 Y39 W42 S62 K86 R93 P316 K317 T318 G320 C321 S322 K323 N324 P326 R351	Q36 Y37 W40 S60 K84 R91 P306 K307 T308 G310 C311 S312 K313 N314 P316 R341
BS02	dna	A	K224 S257 G259 K261 L262 R382	K214 S247 G249 K251 L252 R372
BS03	MG	A	D13 M14 D115	D11 M12 D113
BS04	MG	A	D13 D115 E116	D11 D113 E114
BS05	DZ4	A	D13 M14 C16 F17 F18 I48 Y52 R55 R61 D115 K231	D11 M12 C14 F15 F16 I46 Y50 R53 R59 D113 K221

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:4j9o, PDBe:4j9o, PDBj:4j9o
• PDBsum: 4j9o
• PubMed: 23630267
• UniProt: Q9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)