Structure of PDB 4j8m Chain A

Receptor sequence
>4j8mA (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
KRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGV
EHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQK
LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIAD
FGWSVHAPSSRRDTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV
GKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPML
REVLEHPWITANSSKP
3D structure
PDB4j8m Drugging MYCN through an Allosteric Transition in Aurora Kinase A.
ChainA
Resolution1.853 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D256 K258 E260 N261 D274 T292
Catalytic site (residue number reindexed from 1) D132 K134 E136 N137 D150 T168
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CJ5 A G145 N146 V147 K162 L164 L194 E211 Y212 A213 G216 L263 D274 V279 A281 P282 G21 N22 V23 K38 L40 L70 E87 Y88 A89 G92 L139 D150 V155 A157 P158 MOAD: ic50=48nM
PDBbind-CN: -logKd/Ki=7.32,IC50=48nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000212 meiotic spindle organization
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007052 mitotic spindle organization
GO:0007098 centrosome cycle
GO:0007100 mitotic centrosome separation
GO:0051321 meiotic cell cycle

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Molecular Function
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Biological Process
External links
PDB RCSB:4j8m, PDBe:4j8m, PDBj:4j8m
PDBsum4j8m
PubMed25175806
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA)

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