Structure of PDB 4j8f Chain A

Receptor sequence
>4j8fA (length=551) Species: 9606,10116 [Search protein sequence]
FMAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTER
LIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGD
KPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAY
FNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFD
LGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKH
KKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITR
ARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKL
LQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGLESDLEIDNEGVIEADT
DAPQEMGDENAEITEAMMDEANEKKGAAIDALNDGELQKAIDLFTDAIKL
NPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHR
LLGHWEEAARDLALACKLDYDEDASAMLREVQPRAQKIAEHRRKYERKRE
E
3D structure
PDB4j8f Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D10 K71 E175 D199
Catalytic site (residue number reindexed from 1) D11 K72 E176 D200
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 ADP A T14 Y15 G201 G202 E268 K271 R272 S275 G339 S340 R342 T15 Y16 G202 G203 E269 K272 R273 S276 G340 S341 R343
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0140662 ATP-dependent protein folding chaperone

View graph for
Molecular Function
External links
PDB RCSB:4j8f, PDBe:4j8f, PDBj:4j8f
PDBsum4j8f
PubMed23812373
UniProtP0DMV8|HS71A_HUMAN Heat shock 70 kDa protein 1A (Gene Name=HSPA1A);
P50503

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