Structure of PDB 4j74 Chain A

Receptor sequence
>4j74A (length=86) Species: 8355 (Xenopus laevis) [Search protein sequence]
MEKLVQPTPLLLSLLKSAGAQKETFTMKEVLYHLGQYIMAKQLYDEKQQH
IVHCSNDPLGELFGVQEFSVKEHRRIYAMISRNLVS
3D structure
PDB4j74 Deconstruction of a nutlin: dissecting the binding determinants of a potent protein-protein interaction inhibitor.
ChainA
Resolution1.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I18 A L50 I57 V89 H92 I95 Y96 L31 I38 V70 H73 I76 Y77 MOAD: Kd=26uM
PDBbind-CN: -logKd/Ki=4.59,Kd=26uM
BS02 I18 A M58 Y63 Q68 M39 Y44 Q49 MOAD: Kd=26uM
PDBbind-CN: -logKd/Ki=4.59,Kd=26uM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:4j74, PDBe:4j74, PDBj:4j74
PDBsum4j74
PubMed24900726
UniProtP56273|MDM2_XENLA E3 ubiquitin-protein ligase Mdm2 (Gene Name=mdm2)

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