Structure of PDB 4j53 Chain A

Receptor sequence
>4j53A (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
KEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKS
LLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRS
LLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNED
LEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSI
GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQ
TDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPS
3D structure
PDB4j53 Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1).
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D176 K178 G180 N181 D194 T214
Catalytic site (residue number reindexed from 1) D139 K141 G143 N144 D157 T177
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H93 C212 H56 C175
BS02 1J4 A L59 C67 V114 C133 R136 F183 L22 C30 V77 C96 R99 F146 MOAD: ic50=2nM
PDBbind-CN: -logKd/Ki=8.70,IC50=2nM
BindingDB: IC50=2.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4j53, PDBe:4j53, PDBj:4j53
PDBsum4j53
PubMed23664874
UniProtP53350|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)

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