Structure of PDB 4j52 Chain A

Receptor sequence
>4j52A (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
KEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKS
LLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRS
LLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNED
LEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSI
GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQ
TDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPS
3D structure
PDB4j52 Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1).
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D176 K178 G180 N181 D194 T214
Catalytic site (residue number reindexed from 1) D139 K141 G143 N144 D157 T177
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1J3 A L59 C67 A80 G81 K82 V114 L132 C133 R134 R136 F183 L22 C30 A43 G44 K45 V77 L95 C96 R97 R99 F146 MOAD: ic50=3nM
PDBbind-CN: -logKd/Ki=8.52,IC50=3nM
BindingDB: IC50=3.0nM
BS02 ZN A H93 C212 H56 C175
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4j52, PDBe:4j52, PDBj:4j52
PDBsum4j52
PubMed23664874
UniProtP53350|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)

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