Structure of PDB 4j51 Chain A

Receptor sequence
>4j51A (length=302) Species: 9606 (Homo sapiens) [Search protein sequence]
MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAE
KPKNIKKNRYKDILPYDYSRVELSLITDEDSSYINANFIKGVYGPKAYIA
TQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQL
EFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSS
IDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGI
IPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDKH
SG
3D structure
PDB4j51 A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune Diseases.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D195 C227 R233 T234 Q274
Catalytic site (residue number reindexed from 1) D194 C226 R232 T233 Q273
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N75 A Y60 K61 D62 C227 S228 A229 C231 G232 R233 Q274 Q278 Y60 K61 D62 C226 S227 A228 C230 G231 R232 Q273 Q277 MOAD: ic50=0.259uM
PDBbind-CN: -logKd/Ki=6.59,IC50=0.259uM
BindingDB: IC50=259nM,Ki=110nM
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4j51, PDBe:4j51, PDBj:4j51
PDBsum4j51
PubMed23713581
UniProtQ9Y2R2|PTN22_HUMAN Tyrosine-protein phosphatase non-receptor type 22 (Gene Name=PTPN22)

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