Structure of PDB 4j44 Chain A

Receptor sequence
>4j44A (length=83) Species: 9606 (Homo sapiens) [Search protein sequence]
GTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQC
FACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGR
3D structure
PDB4j44 The structure of XIAP BIR2: understanding the selectivity of the BIR domains.
ChainA
Resolution1.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K206 L207 K208 N209 W210 D214 E219 H223 K56 L57 K58 N59 W60 D64 E69 H73
BS02 ZN A C200 C203 H220 C227 C50 C53 H70 C77
Gene Ontology
Molecular Function
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Biological Process
GO:0043066 negative regulation of apoptotic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4j44, PDBe:4j44, PDBj:4j44
PDBsum4j44
PubMed23999295
UniProtP98170|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)

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