Structure of PDB 4j3i Chain A

Receptor sequence
>4j3iA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4j3i RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist.
ChainA
Resolution1.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1K0 A P82 F83 V87 N140 D144 I146 P41 F42 V46 N99 D103 I105 MOAD: Kd=8.93uM
PDBbind-CN: -logKd/Ki=5.74,IC50=1.8uM
BindingDB: IC50=510nM,Kd=1100nM
External links
PDB RCSB:4j3i, PDBe:4j3i, PDBj:4j3i
PDBsum4j3i
PubMed24391744
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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