Structure of PDB 4j3e Chain A

Receptor sequence
>4j3eA (length=86) Species: 8355 (Xenopus laevis) [Search protein sequence]
MEKLVQPTPLLLSLLKSAGAQKETFTMKEVLYHLGQYIMAKQLYDEKQQH
IVHCSNDPLGELFGVQEFSVKEHRRIYAMISRNLVS
3D structure
PDB4j3e Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development.
ChainA
Resolution1.91 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NUT A L50 L53 G54 I57 M58 F87 V89 H92 Y96 L31 L34 G35 I38 M39 F68 V70 H73 Y77 MOAD: ic50=0.088uM
PDBbind-CN: -logKd/Ki=7.06,IC50=0.088uM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:4j3e, PDBe:4j3e, PDBj:4j3e
PDBsum4j3e
PubMed24900694
UniProtP56273|MDM2_XENLA E3 ubiquitin-protein ligase Mdm2 (Gene Name=mdm2)

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