Structure of PDB 4j1l Chain A

Receptor sequence
>4j1lA (length=391) Species: 212717 (Clostridium tetani E88) [Search protein sequence]
PITINNFRYSDPVNNDTIIMMEPPYCKGLDIYYKAFKITDRIWIVPERYE
FGTKPEDFNPPSSEYYDPNYLRTDSDKDRFLQTMVKLFNRIKNNVAGEAL
LDKIINAIPYLGNSYSLLDKFDTNSNSVSFNLLEQDPSGATTKSAMLTNL
IIFGPGPVLNENEVRGIVLRVDNKNYFPCRDGFGSIMQMAFCPEYVPTFD
NSKYFQDPALILMHELIHVLHGLYGMQVSSHSAEELFTFGGQDANLISID
IKNDLYEKTLNDYKAIANKLSQVTSCNDPNIDIDSYKQIYQQKYQFDKDS
NGQYIVNEDKFQILYNSIMYGFTEVELGKKFNIKTRLSYFSMNHDPVKIP
NLLDDTIYNDTEGFNIESKDLKSEYKGQNMRVNTNAFRNVD
3D structure
PDB4j1l Engineering Clostridia Neurotoxins with elevated catalytic activity
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H233 E234 H237 E271 R372
Catalytic site (residue number reindexed from 1) H214 E215 H218 E235 R336
Enzyme Commision number 3.4.24.68: tentoxilysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H233 H237 E271 H214 H218 E235
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4j1l, PDBe:4j1l, PDBj:4j1l
PDBsum4j1l
PubMed23994593
UniProtP04958|TETX_CLOTE Tetanus toxin (Gene Name=tetX)

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