Structure of PDB 4izc Chain A

Receptor sequence
>4izcA (length=251) Species: 246200 (Ruegeria pomeroyi DSS-3) [Search protein sequence]
QDVTSGYSNLDLDLRDNGVCVVTLNRPDKRNALDVATIEELVTFFSTAHR
KGVRAVVLTGAGDHFCAGLDLVEHWKADRSADDFMHVCLRWHEAFNKMEY
GGVPIIAALRGAVVGGGLALASAAHLRVMDQSTYFALPEGQRGIFTGGGA
TIRVSDMIGKYRMIDMILTGRVYQGQEAADLGLAQYITEGSSFDKAMELA
DKIASNLPLTNFAICSAISHMQNMSGLDAAYAEAFVGGIVNTQPAARERL
E
3D structure
PDB4izc Crystal Structure of DmdD, a Crotonase Superfamily Enzyme That Catalyzes the Hydration and Hydrolysis of Methylthioacryloyl-CoA.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) L71 H76 C90 H94 G118 A121 E141 G149 Y233
Catalytic site (residue number reindexed from 1) L69 H74 C88 H92 G116 A119 E139 G147 Y231
Enzyme Commision number 4.2.1.155: methylthioacryloyl-CoA hydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1GZ A K31 R32 A34 A69 G70 L71 D72 L73 V116 G117 G118 T148 G149 K29 R30 A32 A67 G68 L69 D70 L71 V114 G115 G116 T146 G147
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004300 enoyl-CoA hydratase activity
GO:0016829 lyase activity
GO:0016836 hydro-lyase activity
Biological Process
GO:0006635 fatty acid beta-oxidation
GO:0034214 protein hexamerization

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Molecular Function
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Biological Process
External links
PDB RCSB:4izc, PDBe:4izc, PDBj:4izc
PDBsum4izc
PubMed23704947
UniProtQ5LLW6|DMDD_RUEPO Methylthioacryloyl-CoA hydratase (Gene Name=dmdD)

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