Structure of PDB 4iy6 Chain A

Receptor sequence
>4iy6A (length=263) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFK
YKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITYVREEVI
DFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRS
KIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI
EQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLSEQGLLDKL
KNKWWYDKGECGS
3D structure
PDB4iy6 Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain
ChainA
Resolution1.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MQR A P105 F106 S108 S217 K218 P105 F106 S108 S217 K218
BS02 MQS A Q130 T131 I133 Y161 Q130 T131 I133 Y161
BS03 MQS A K116 G118 T119 P120 K185 G186 K187 K116 G118 T119 P120 K185 G186 K187
BS04 GLU A Y61 L90 T91 R96 G141 S142 T143 E193 Y61 L90 T91 R96 G141 S142 T143 E193
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4iy6, PDBe:4iy6, PDBj:4iy6
PDBsum4iy6
PubMed23999288
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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