Structure of PDB 4iwh Chain A

Receptor sequence
>4iwhA (length=358) Species: 271848 (Burkholderia thailandensis E264) [Search protein sequence]
HHHMKIAVLPGDGIGPEIVNEAVKVLNALDEKFELEHAPVGGAGYEASGH
PLPDATLALAKEADAILFGAVGDWKYDSLERALRPEQAILGLRKHLELFA
NFRPAICYPQLVDASPLKPELVAGLDILIVRELNGDIYFGQPRGVRAAPD
GPFAGEREGFDTMRYSEPEVRRIAHVAFQAAQKRAKKLLSVDKSNVLETS
QFWRDVMIDVSKEYADVELSHMYVDNAAMQLAKAPKQFDVIVTGNMFGDI
LSDEASMLTGSIGMLPSASLDKNNKGLYEPSHGSAPDIAGKGIANPLATI
LSAAMLLRYSLNRAEQADRIERAVKTVLEQGYRTGDIATPGCRQVGTAAM
GDAVVAAL
3D structure
PDB4iwh Crystal structure of a 3-isopropylmalate dehydrogenase from Burkholderia pseudomallei
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y135 K190 D222 D246 D250
Catalytic site (residue number reindexed from 1) Y138 K193 D225 D249 D253
Enzyme Commision number 1.1.1.85: 3-isopropylmalate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D246 D250 D249 D253
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003862 3-isopropylmalate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0009098 L-leucine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4iwh, PDBe:4iwh, PDBj:4iwh
PDBsum4iwh
PubMed
UniProtQ2T7H6|LEU3_BURTA 3-isopropylmalate dehydrogenase (Gene Name=leuB)

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