Structure of PDB 4iw8 Chain A

Receptor sequence
>4iw8A (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNS
GVYTFTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLL
ILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB4iw8 Ligand binding dynamics rewire cellular signaling via Estrogen Receptor-alpha
ChainA
Resolution2.0375 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 L372 V376 L379 E380 E542 M543 I54 L68 V72 L75 E76 E233 M234
BS02 KN3 A E353 L387 M388 L391 R394 M421 G521 E49 L83 M84 L87 R90 M115 G212
External links
PDB RCSB:4iw8, PDBe:4iw8, PDBj:4iw8
PDBsum4iw8
PubMed23524984
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

[Back to BioLiP]