Structure of PDB 4iw6 Chain A

Receptor sequence
>4iw6A (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
NSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRE
LVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLL
FAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIIL
LNSGVYTDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIR
HMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB4iw6 Ligand binding dynamics rewire cellular signaling via Estrogen Receptor-alpha
ChainA
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 V376 E380 D538 L539 E542 I55 K59 V73 E77 D223 L224 E227
BS02 1GU A L346 A350 E353 L387 F404 M421 I424 G521 H524 L525 L540 L43 A47 E50 L84 F101 M118 I121 G206 H209 L210 L225
External links
PDB RCSB:4iw6, PDBe:4iw6, PDBj:4iw6
PDBsum4iw6
PubMed23524984
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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