Structure of PDB 4ivw Chain A

Receptor sequence
>4ivwA (length=234) Species: 9606 (Homo sapiens) [Search protein sequence]
KNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADR
ELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKL
LFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSII
LLNSGVYTDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHI
RHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB4ivw Ligand binding dynamics rewire cellular signaling via Estrogen Receptor-alpha
ChainA
Resolution2.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 V376 E380 D538 L539 E542 I56 K60 V74 E78 D224 L225 E228
BS02 1GJ A L346 T347 A350 E353 L387 F404 M421 I424 G521 H524 L525 L540 L44 T45 A48 E51 L85 F102 M119 I122 G207 H210 L211 L226
External links
PDB RCSB:4ivw, PDBe:4ivw, PDBj:4ivw
PDBsum4ivw
PubMed23524984
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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