Structure of PDB 4iv4 Chain A

Receptor sequence
>4iv4A (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSTRPFSEASMMGLLTNLADRELVHMI
NWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNL
LLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGV
YTFKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMS
NKGMEHLYSMKCKNVPLSDLLLEMLDAHR
3D structure
PDB4iv4 Ligand binding dynamics rewire cellular signaling via Estrogen Receptor-alpha
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 Q375 V376 L379 E380 D538 L539 E542 I50 K54 Q67 V68 L71 E72 D219 L220 E223
BS02 1GS A L346 E353 L387 M421 G521 H524 L38 E45 L79 M113 G203 H206
External links
PDB RCSB:4iv4, PDBe:4iv4, PDBj:4iv4
PDBsum4iv4
PubMed23524984
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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