Structure of PDB 4iv2 Chain A

Receptor sequence
>4iv2A (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHM
SNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB4iv2 Ligand binding dynamics rewire cellular signaling via Estrogen Receptor-alpha
ChainA
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 V376 E380 D538 E542 I54 V72 E76 D221 E225
BS02 1GR A L346 E353 L387 M388 R394 F404 M421 I424 H524 L42 E49 L83 M84 R90 F100 M117 I120 H207
External links
PDB RCSB:4iv2, PDBe:4iv2, PDBj:4iv2
PDBsum4iv2
PubMed23524984
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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