Structure of PDB 4iu7 Chain A

Receptor sequence
>4iu7A (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
NSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRE
LVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLL
FAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIIL
LNSGVYTFKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSH
IRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB4iu7 Ligand binding dynamics rewire cellular signaling via Estrogen Receptor-alpha
ChainA
Resolution2.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L372 V376 E380 E542 I55 K59 L69 V73 E77 E229
BS02 1GM A L346 A350 E353 L387 F404 M421 G521 L525 L43 A47 E50 L84 F101 M118 G208 L212
External links
PDB RCSB:4iu7, PDBe:4iu7, PDBj:4iu7
PDBsum4iu7
PubMed23524984
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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