Structure of PDB 4iu6 Chain A

Receptor sequence
>4iu6A (length=304) Species: 9606 (Homo sapiens) [Search protein sequence]
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKL
LSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHG
DLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHA
QANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMI
CEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARP
HFMS
3D structure
PDB4iu6 Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D229 D240 H303 H310 E336 E367
Catalytic site (residue number reindexed from 1) D140 D151 H214 H221 E247 E278
Enzyme Commision number 3.4.11.18: methionyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO A D240 H303 T334 E336 E367 D151 H214 T245 E247 E278
BS02 CO A D229 D240 E367 D140 D151 E278
BS03 FZ1 A K132 Y195 Y196 C203 H212 H310 W353 K43 Y106 Y107 C114 H123 H221 W264 BindingDB: IC50=100nM
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0004239 initiator methionyl aminopeptidase activity
GO:0005515 protein binding
GO:0008235 metalloexopeptidase activity
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006417 regulation of translation
GO:0006508 proteolysis
GO:0018206 peptidyl-methionine modification
GO:0031365 N-terminal protein amino acid modification
GO:0051604 protein maturation
GO:0070527 platelet aggregation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0022626 cytosolic ribosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4iu6, PDBe:4iu6, PDBj:4iu6
PDBsum4iu6
PubMed23634668
UniProtP53582|MAP11_HUMAN Methionine aminopeptidase 1 (Gene Name=METAP1)

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