Structure of PDB 4itj Chain A

Receptor sequence
>4itjA (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
NVIKMKSSDFLEFGKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAK
MMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVK
GRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMW
SKLNGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIA
EQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEE
KFRPFYLSQLE
3D structure
PDB4itj Structural Basis of RIP1 Inhibition by Necrostatins.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 E142 N143 D156 T189
Catalytic site (residue number reindexed from 1) D123 K125 E127 N128 D141 T156
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1HX A M67 L70 V76 L78 M92 I154 A155 D156 S161 F162 M52 L55 V61 L63 M77 I139 A140 D141 S146 F147 MOAD: ic50=0.3772uM
PDBbind-CN: -logKd/Ki=6.42,IC50=377.2nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4itj, PDBe:4itj, PDBj:4itj
PDBsum4itj
PubMed23473668
UniProtQ13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (Gene Name=RIPK1)

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