Structure of PDB 4iti Chain A

Receptor sequence
>4itiA (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
NVIKMKSSDFLESAELDSGGFGKVSLAFHRTQGLMIMKTVYKGPNCIEHN
EALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAE
MSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADL
GLASFKMWSKLNNEEHNELGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVV
LWAIFANKEPYEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANP
EARPTFPGIEEKFRPFYLSQLE
3D structure
PDB4iti Structural Basis of RIP1 Inhibition by Necrostatins.
ChainA
Resolution2.86 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 E142 N143 D156 T189
Catalytic site (residue number reindexed from 1) D131 K133 E135 N136 D149 T172
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1HW A A64 M67 V76 L78 L90 M92 H136 I154 A155 D156 L157 S161 F162 A57 M60 V69 L71 L83 M85 H129 I147 A148 D149 L150 S154 F155 PDBbind-CN: -logKd/Ki=6.36,IC50=439.5nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4iti, PDBe:4iti, PDBj:4iti
PDBsum4iti
PubMed23473668
UniProtQ13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (Gene Name=RIPK1)

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