Structure of PDB 4irz Chain A

Receptor sequence
>4irzA (length=592) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
YNVDTESALLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTANWLANASVI
NPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTLSR
QPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRIAPC
YQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTN
KYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYI
FSIDEKELNILHEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTI
REEGRVFVYINSGSGAVMNAMETNLVGSDKYAARFGESIVNLGDIDNDGF
EDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEGLQISKSLSMFGQS
ISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVNRTK
FDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRF
YFSSNGTSDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHL
GPHVISKASTEEFPPLQPILQQKKEKDIMKKTINFARTGGLE
3D structure
PDB4irz How natalizumab binds and antagonizes alpha 4 integrins.
ChainA
Resolution2.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D281 N283 D285 F287 S288 D289 D281 N283 D285 F287 S288 D289
BS02 CA A D344 D346 D348 F350 D352 D344 D346 D348 F350 D352
BS03 CA A D406 D408 N410 Y412 D414 D406 D408 N410 Y412 D414
BS04 NDS A Y21 T97 Y220 Y21 T97 Y220
Gene Ontology
Cellular Component
GO:0008305 integrin complex

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Biological Process
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Cellular Component
External links
PDB RCSB:4irz, PDBe:4irz, PDBj:4irz
PDBsum4irz
PubMed24047894
UniProtG1TY34

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