Structure of PDB 4irv Chain A

Receptor sequence
>4irvA (length=197) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
QQFINNLQVAFIKVDNVVASFDPDQKPIVDKNDRDNRQAFDGISQLREEY
SNKAIKNPTKKNQYFSDFIDKSNDLINKDNLIDVESSTKSFQKFGDQRYQ
IFTSWVSHQKDPSKINTRSIRNFMENIIQPPIPDDKEKAEFLKSAKQSFA
GIIIGNQIRTDQKFMGVFDESLKERQEAEKGGPTGGDWLDIFLSFIF
3D structure
PDB4irv Structure of the Helicobacter pylori CagA oncoprotein bound to the human tumor suppressor ASPP2.
ChainA
Resolution2.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F26 I105 V107 E108 T111 F114 D119 Q123 T126 S127 S130 Q170 S171 G174 I175 P207 T208 G209 G210 I215 S218 F219 F221 F3 I82 V84 E85 T88 F91 D96 Q100 T103 S104 S107 Q147 S148 G151 I152 P183 T184 G185 G186 I191 S194 F195 F197
Gene Ontology
Molecular Function
GO:0019534 toxin transmembrane transporter activity

View graph for
Molecular Function
External links
PDB RCSB:4irv, PDBe:4irv, PDBj:4irv
PDBsum4irv
PubMed24474782
UniProtP55980|CAGA_HELPY Cytotoxicity-associated immunodominant antigen (Gene Name=cagA)

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