Structure of PDB 4irq Chain A

Receptor sequence
>4irqA (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
EHWEEDASWGPHRLAVLVPFRERFEELLVFVPHMRRFLSRKKIRHHIYVL
NQVDHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLNEELDYGFPEAG
PFHVASPELHPLYHYKTYVGGILLLSKQHYRLCNGMSNRFWGWGREDDEF
YRRIKGAGLQLFRPSGITTGYKTFRHLHDPAWRKRDQKRIAAQKQEQFKV
DREGGLNTVKYHVASRTALSVGGAPCTVLNIMLDCDKTATPWCTFS
3D structure
PDB4irq Crystal structures of beta-1,4-galactosyltransferase 7 enzyme reveal conformational changes and substrate binding.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D163 D165 W224 E227 D228 T254 H257 H259
Catalytic site (residue number reindexed from 1) D82 D84 W143 E146 D147 T173 H176 H178
Enzyme Commision number 2.4.1.-
2.4.1.133: xylosylprotein 4-beta-galactosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D165 H257 H259 D84 H176 H178
BS02 UDP A P100 F101 R102 R104 F139 D163 V164 D165 Y194 H257 H259 R266 P19 F20 R21 R23 F58 D82 V83 D84 Y113 H176 H178 R185
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4irq, PDBe:4irq, PDBj:4irq
PDBsum4irq
PubMed24052259
UniProtQ9UBV7|B4GT7_HUMAN Beta-1,4-galactosyltransferase 7 (Gene Name=B4GALT7)

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