Structure of PDB 4irp Chain A

Receptor sequence
>4irpA (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]
GSDIPEHWEEDASWGPHRLAVLVPFRERFEELLVFVPHMRRFLSRKKIRH
HIYVLNQVDHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLNEELDYG
FPEAGPFHVASPELHPLYHYKTYVGGILLLSKQHYRLCNGMSNRFWGWGR
EDDEFYRRIKGAGLQLFRPSGITTGYKTFRHLHFKVDREGGLNTVKYHVA
SRTALSVGGAPCTVLNIMLDCDKTATPWCTFS
3D structure
PDB4irp Crystal Structures of beta-1,4-Galactosyltransferase 7 Enzyme Reveal Conformational Changes and Substrate Binding.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D163 D165 W224 E227 D228 T254 H257 H259
Catalytic site (residue number reindexed from 1) D87 D89 W148 E151 D152 T178 H181 H183
Enzyme Commision number 2.4.1.-
2.4.1.133: xylosylprotein 4-beta-galactosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDP A P100 F101 R102 R104 F139 D163 V164 D165 Y194 P24 F25 R26 R28 F63 D87 V88 D89 Y118
BS02 MN A D165 H257 D89 H181
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4irp, PDBe:4irp, PDBj:4irp
PDBsum4irp
PubMed24052259
UniProtQ9UBV7|B4GT7_HUMAN Beta-1,4-galactosyltransferase 7 (Gene Name=B4GALT7)

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