Structure of PDB 4iqx Chain A

Receptor sequence

>4iqxA (length=476) Species: 12116 (Foot and mouth disease virus C)

GLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDSRLNEGV
VLDEVIFSKHKGDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRSMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGIPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAALAHH

3D structure

• PDB: 4iqx A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape.
• Chain: A
• Resolution: 2.5 Å

Enzymatic activity

• Enzyme Commision number: 3.4.22.46: L-peptidase.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	K20 L108 D109 T115 A116 R128 F162 K164 D165 V181 R193 H204 G216 C217 N218 G299 C300 S301 Y336 R416	K20 L108 D109 T115 A116 R128 F162 K164 D165 V181 R193 H204 G216 C217 N218 G299 C300 S301 Y336 R416
BS02	rna	A	Y336 D338 D339 L386 K387 I411 R416 K423 S426	Y336 D338 D339 L386 K387 I411 R416 K423 S426

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:4iqx, PDBe:4iqx, PDBj:4iqx
• PDBsum: 4iqx
• PubMed: 20865120
• UniProt: Q9QCE4