Structure of PDB 4iqj Chain A

Receptor sequence
>4iqjA (length=1164) Species: 271 (Thermus aquaticus) [Search protein sequence]
LKFAHLHQHTQFSLLDGAAKLQDLLKWVKETTPEDPALAMTDHGNLFGAV
EFYKKATAMGVKPIIGYEAYVAAESRFDRGYFHLTLLAKDFTGYQNLVRL
ASRAYLEGFYEKPRIDREILREHAQGLIALSGCLGAEIPQFILQDRLDLA
EARLNEDLSIFGDRFFIEIQNHGLPEQKKVNQVLKEFARKYGLGMVATND
GHYVRKEDARAHEVLLAIQSKTTLDDPERWRFPCDEFYVKTPEEMRAMLP
EAEWGDEPFDNTVEIARMCDVDLPIGDKMVYRIPRFPLPEGRTEAQYLRE
LTFLGLLRRYPDRITEAFYREVLRLLDERALAEALARVEEKAWEELRKRE
WTAEAILHRALYELSVIERMGFPGYFLIVQDYINWARGHGVSVGPGRGSA
AGSLVAYAVGITNIDPLRFGLLFERFLNPERVSMPDIDTDFSDRERDRVI
QYVRERYGEDKVAQIGTFGSLASKAALKDVARVYGIPHKKAEELAKLIPK
PLQEAELRAEMEKDERIRQVIEVAMRLEGLNRHASVHAAGVVIAAEPLTD
LVPLMRDQEGRPVTQYDMGAVEALGLLKMDFLGLRTLTFLDEARRIVKES
KGVELDYDRLPLDDPKTFELLSRGETKGVFQLESGGMTATVRGLKPRRLE
DIIALVSLYRPGPMEHIPTYIRRHHGQEPVSYAEFPHAEKYLRPILDETY
GIPVYQEQIMQIASQVAGYSLGEADLLRRAMGKKRVEEMQKHRERFVRGA
KERGVPEEEANRLFDMLEAFANYGFNKSHAAAYSLLSYQTAYVKAHYPVE
FMAALLSVERHDSDKVAEYIRDARALGIPVLPPDVNRSGFDFKVVGEEIL
FGLSAVKNVGEMAARAILEERERGGPFKSLGDFLKRLPEQVVNKRALESL
VKAGALDAFGDRARLLASLEPLLRWAAETRERGRSGLVGLFAEVEEPPLV
EASPLDEITMLRYEKEALGIYVSGHPVLRYPGLREVASCTIEELSEFVRE
LPGKPKVLLSGMVEEVRFTLSDETGALEVVVFGRAYEGVSPKLKEDIPLL
VLAEVERVLAQAVWTLEEVLEAPKALEVEVDHALLDEKGVARLKSLLDEH
PGSLPVYLRVLGPFGEALFALREVRGEEALGLLEAEGYRAYLVPDREVFL
QGNGGGPKEEVVPF
3D structure
PDB4iqj Structure of PolIIIalpha-Tauc-DNA complex suggests an atomic model of the replisome
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A K233 V510 Y511 K221 V483 Y484
BS02 dna A Y511 R1067 Y484 R1017
BS03 ZN A E72 H95 E68 H83
BS04 ZN A D20 H47 H214 D16 H43 H202
BS05 ZN A H11 H13 E72 D212 H7 H9 E68 D200
BS06 MG A D463 D465 K616 D618 D436 D438 K578 D580
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4iqj, PDBe:4iqj, PDBj:4iqj
PDBsum4iqj
PubMed23478062
UniProtQ9XDH5|DPO3A_THEAQ DNA polymerase III subunit alpha (Gene Name=dnaE)

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