Structure of PDB 4ipf Chain A

Receptor sequence
>4ipfA (length=85) Species: 8355 (Xenopus laevis) [Search protein sequence]
EKLVQPTPLLLSLLKSAGAQKETFTMKEVLYHLGQYIMAKQLYDEKQQHI
VHCSNDPLGELFGVQEFSVKEHRRIYAMISRNLVS
3D structure
PDB4ipf MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1F0 A L50 L53 I57 M58 Q68 H69 F87 V89 H92 Y96 L30 L33 I37 M38 Q48 H49 F67 V69 H72 Y76 MOAD: ic50=18nM
PDBbind-CN: -logKd/Ki=7.74,IC50=18nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4ipf, PDBe:4ipf, PDBj:4ipf
PDBsum4ipf
PubMed23400593
UniProtP56273|MDM2_XENLA E3 ubiquitin-protein ligase Mdm2 (Gene Name=mdm2)

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