Structure of PDB 4in9 Chain A

Receptor sequence
>4in9A (length=162) Species: 28112 (Tannerella forsythia) [Search protein sequence]
YVLQGSKWNKTTLKYYIYNLTTTERENAIRSAFALWSDKSTLSFIQVYNP
NQADIKIKWEKGNHGDGYPFDGNTGILAHAFYPPPAGGNYAGHLHFDDDE
NWSINGSGIDLITVAAHEIGHLLGIEHSNVSSALMYPYYTGIKRQLDNDD
CLAVWDLYGYPF
3D structure
PDB4in9 Structure of the catalytic domain of the Tannerella forsythia matrix metallopeptidase karilysin in complex with a tetrapeptidic inhibitor.
ChainA
Resolution1.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H155 E156 H159 H165
Catalytic site (residue number reindexed from 1) H117 E118 H121 H127
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L115 A116 V152 H155 E156 H159 H165 P175 Y176 Y177 L77 A78 V114 H117 E118 H121 H127 P137 Y138 Y139
BS02 ZN A H155 H159 H165 H117 H121 H127
BS03 ZN A H102 D104 H117 H133 H64 D66 H79 H95
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix

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Cellular Component
External links
PDB RCSB:4in9, PDBe:4in9, PDBj:4in9
PDBsum4in9
PubMed23695557
UniProtD0EM77|KLY_TANFA Karilysin (Gene Name=kly)

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