Structure of PDB 4ilk Chain A

Receptor sequence
>4ilkA (length=337) Species: 199310 (Escherichia coli CFT073) [Search protein sequence]
GSHMKSILIEKPNQLSIIEREIPTPSAGEVRVKVKLAGICGSDSHIYRGH
NPYPRVIGHEFFGVIDAVGEGVESARVGERVAVDPVVSCGHCYPCSIGKP
NVCTTLAVLGVHADGGFSEYAVVPAKNAWKIPEAVADQYAVMIEPFTIAA
NVTGHGQPTENDTVLVYGAGPIGLTIVQVLKGVYNVKNVIVADRIDERLE
KAKESGADWAINNSQTPLGESFAEKGIKPTLIIDAACHPSILKEAVTLAS
PAARIVLMGFSSEPSEVIQQGITGKELSIFSSRLNANKFPVVIDWLSKGL
IKPEKLITHTFDFQHVADAISLFELDQKHCCKVLLTF
3D structure
PDB4ilk Crystal structure of short chain alcohol dehydrogenase (rspB) from E. coli CFT073 (EFI TARGET EFI-506413) complexed with cofactor NADH
ChainA
Resolution2.003 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C37 G38 S39 H42 H59 E60 C89 C92 C95 C103 A107 P145 A149 K332
Catalytic site (residue number reindexed from 1) C40 G41 S42 H45 H59 E60 C89 C92 C95 C103 A107 P145 A149 K332
Enzyme Commision number 1.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI A G168 G170 P171 I172 D193 R194 R198 N213 A235 A236 C237 I241 M258 F260 G168 G170 P171 I172 D193 R194 R198 N213 A235 A236 C237 I241 M258 F260
BS02 MN A C37 H59 E60 E144 C40 H59 E60 E144
BS03 ZN A C89 C92 C95 C103 C89 C92 C95 C103
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:4ilk, PDBe:4ilk, PDBj:4ilk
PDBsum4ilk
PubMed
UniProtA0A0H2V9Q5

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