Structure of PDB 4ijl Chain A

Receptor sequence

>4ijlA (length=122) Species: 9606 (Homo sapiens)

SHMVGQLSRGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSD
GLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILME
LEVLKSAEAVGVKIGNPVPYNE

3D structure

• PDB: 4ijl Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A.
• Chain: A
• Resolution: 1.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	1EK	A	R41 A59 T60 N85	R43 A61 T62 N87	MOAD: Kd=135uM PDBbind-CN: -logKd/Ki=3.87,Kd=135uM BindingDB: Kd=135000nM
BS02	1EK	A	R31 R43 S55 V93	R33 R45 S57 V95	MOAD: Kd=135uM PDBbind-CN: -logKd/Ki=3.87,Kd=135uM BindingDB: Kd=135000nM

Gene Ontology

Molecular Function

• GO:0003677 DNA binding

Biological Process

• GO:0006260 DNA replication

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:4ijl, PDBe:4ijl, PDBj:4ijl
• PDBsum: 4ijl
• PubMed: 23914285
• UniProt: P27694|RFA1_HUMAN Replication protein A 70 kDa DNA-binding subunit (Gene Name=RPA1)