Structure of PDB 4ijh Chain A

Receptor sequence

>4ijhA (length=123) Species: 9606 (Homo sapiens)

GSHMVGQLSRGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMS
DGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILM
ELEVLKSAEAVGVKIGNPVPYNE

3D structure

• PDB: 4ijh Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A.
• Chain: A
• Resolution: 1.498 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	1EJ	A	R31 I33 T34 R43 S55 M57 L87 D89 R91 V93	R34 I36 T37 R46 S58 M60 L90 D92 R94 V96	MOAD: Kd=47uM PDBbind-CN: -logKd/Ki=4.33,Kd=47uM
BS02	1EJ	A	R41 L87 K88 V93	R44 L90 K91 V96	MOAD: Kd=47uM PDBbind-CN: -logKd/Ki=4.33,Kd=47uM
BS03	1EJ	A	R43 R91	R46 R94	MOAD: Kd=47uM PDBbind-CN: -logKd/Ki=4.33,Kd=47uM

Gene Ontology

Molecular Function

• GO:0003677 DNA binding

Biological Process

• GO:0006260 DNA replication

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:4ijh, PDBe:4ijh, PDBj:4ijh
• PDBsum: 4ijh
• PubMed: 23914285
• UniProt: P27694|RFA1_HUMAN Replication protein A 70 kDa DNA-binding subunit (Gene Name=RPA1)