Structure of PDB 4ij8 Chain A

Receptor sequence
>4ij8A (length=161) Species: 9606 (Homo sapiens) [Search protein sequence]
RKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDF
VVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETN
RLGRLINHSKSGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSK
ASIEAHPWLKH
3D structure
PDB4ij8 Crystal structure of the complex of SETD8 with SAM
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R279 G280 Q347 S364 R47 G48 Q115 S132
BS02 SAM A G266 K267 R269 C311 Y312 R336 L337 N339 H340 Y377 W390 G34 K35 R37 C79 Y80 R104 L105 N107 H108 Y145 W158
Gene Ontology
Molecular Function
GO:0042799 histone H4K20 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4ij8, PDBe:4ij8, PDBj:4ij8
PDBsum4ij8
PubMed
UniProtQ9NQR1|KMT5A_HUMAN N-lysine methyltransferase KMT5A (Gene Name=KMT5A)

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