Structure of PDB 4iiu Chain A

Receptor sequence
>4iiuA (length=243) Species: 199310 (Escherichia coli CFT073) [Search protein sequence]
MSRSVLVTGASKGIGRAIARQLAADGFNIGVHYHRDAAGAQETLNAIVAN
GGNGRLLSFDVANREQCREVLEHEIAQHGAWYGVVSNAGIARDAAFPALS
NDDWDAVIHTNLDSFYNVIQPCIMPMIGARQGGRIITLSSVSGVMGNRGQ
VNYSAAKAGIIGATKALAIELAKRKITVNCIAPGLIDTGMIEMEESALKE
AMSMIPMKRMGQAEEVAGLASYLMSDIAGYVTRQVISINGGML
3D structure
PDB4iiu Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from Escherichia coli strain CFT073 complexed with NADP+ at 2.1 A resolution
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G13 S140 Y153 K157
Catalytic site (residue number reindexed from 1) G13 S140 Y153 K157
Enzyme Commision number 1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G9 S11 K12 G13 I14 H32 H34 D36 D60 V61 N87 A88 G89 I90 S140 Y153 K157 P183 G184 I186 T188 M190 I191 G9 S11 K12 G13 I14 H32 H34 D36 D60 V61 N87 A88 G89 I90 S140 Y153 K157 P183 G184 I186 T188 M190 I191
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016597 amino acid binding
GO:0016743 carboxyl- or carbamoyltransferase activity
Biological Process
GO:0006520 amino acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4iiu, PDBe:4iiu, PDBj:4iiu
PDBsum4iiu
PubMed
UniProtA0A0H2V833

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