Structure of PDB 4igt Chain A

Receptor sequence
>4igtA (length=263) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFK
YKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVI
DFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRS
KIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI
EQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKL
KNKWWYDKGECGS
3D structure
PDB4igt Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters.
ChainA
Resolution1.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3ZA A Y471 P499 T501 R506 G674 S675 T676 E726 Y753 Y61 P89 T91 R96 G141 S142 T143 E193 Y220 MOAD: Kd=12.8nM
PDBbind-CN: -logKd/Ki=7.89,Kd=12.8nM
BindingDB: Ki=126000nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:4igt, PDBe:4igt, PDBj:4igt
PDBsum4igt
PubMed23414088
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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