Structure of PDB 4if6 Chain A

Receptor sequence

>4if6A (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]

MRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYAR
LAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIAL
SDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEA
VRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDE
VDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDC
DVIINELCHRLGGEYAKLCCNPVKLSEI

3D structure

PDB

4if6 Structure of a nucleoporin complex

Chain

Resolution

2.25 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	P271 D272 F273 R274 N346 D348 H363
Catalytic site (residue number reindexed from 1)	P39 D40 F41 R42 N114 D116 H131
Enzyme Commision number	2.3.1.- 2.3.1.286: protein acetyllysine N-acetyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	K236 N241 T242 I243 R466 P468 D475 E477 L479 G480 D481 I485	K4 N9 T10 I11 R234 P236 D243 E245 L247 G248 D249 I253
BS02	ZN	A	C371 C374 C395 C398	C139 C142 C163 C166
BS03	APR	A	G261 A262 G263 V266 D272 F273 R274 Y280 Q345 H363 G440 S441 S442 V445 N465 R466 E467 G480 D481 C482	G29 A30 G31 V34 D40 F41 R42 Y48 Q113 H131 G208 S209 S210 V213 N233 R234 E235 G248 D249 C250

Gene Ontology

	Molecular Function
GO:0070403	NAD+ binding

View graph for
Molecular Function

External links

PDB	RCSB:4if6, PDBe:4if6, PDBj:4if6
PDBsum	4if6
PubMed
UniProt	Q96EB6\|SIR1_HUMAN NAD-dependent protein deacetylase sirtuin-1 (Gene Name=SIRT1)

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