Structure of PDB 4ieh Chain A

Receptor sequence
>4iehA (length=138) Species: 9606 (Homo sapiens) [Search protein sequence]
YDNREIVMKYIHYKLSQRGYEWDSEVVHLTLRQAGDDFSRRYRRDFAEMS
SQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREM
SPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGP
3D structure
PDB4ieh The role of the acidity of N-heteroaryl sulfonamides as inhibitors of bcl-2 family protein-protein interactions.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1E9 A A59 D62 F63 R66 Y67 M74 L96 G104 V107 Y161 A34 D37 F38 R41 Y42 M49 L71 G79 V82 Y136 MOAD: Kd=14nM
PDBbind-CN: -logKd/Ki=7.85,Kd=14nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:4ieh, PDBe:4ieh, PDBj:4ieh
PDBsum4ieh
PubMed24900652
UniProtP10415|BCL2_HUMAN Apoptosis regulator Bcl-2 (Gene Name=BCL2);
Q07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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