Structure of PDB 4ieb Chain A

Receptor sequence
>4iebA (length=472) Species: 5811 (Toxoplasma gondii) [Search protein sequence]
LHATPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKV
ISKRQVTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVMEVYTGG
ELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLES
KSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVW
STGVILYILLSGCPPFNGANEYDILKKVEKGKYTFEPQWKKVSESAKDLI
RKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQG
TQKLAQAALLYMGSKLTSQDETKELTAIFHKMDKNGDGQLDRAELIEGYK
ELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNGYIEYSEFVTVAMDRK
TLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSVLSEVD
KNNDGEVDFDEFQQMLLLCGNL
3D structure
PDB4ieb Crystal Structure of a Gly128Met mutant of the toxoplasma CDPK, TGME49_101440
ChainA
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D174 K176 E178 N179 D195 T214
Catalytic site (residue number reindexed from 1) D140 K142 E144 N145 D161 T180
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D415 D417 N419 Y421 E423 E426 D380 D382 N384 Y386 E388 E391
BS02 CA A D368 N370 D372 Q374 E379 D333 N335 D337 Q339 E344
BS03 CA A D451 D453 S455 K457 E462 D416 D418 S420 K422 E427
BS04 CA A D485 N487 D489 E491 E496 D450 N452 D454 E456 E461
BS05 ANP A A78 K80 Y131 L181 A47 K49 Y97 L147
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calcium/calmodulin-dependent protein kinase activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0009931 calcium-dependent protein serine/threonine kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ieb, PDBe:4ieb, PDBj:4ieb
PDBsum4ieb
PubMed
UniProtQ9BJF5

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