Structure of PDB 4ibw Chain A

Receptor sequence
>4ibwA (length=197) Species: 9606 (Homo sapiens) [Search protein sequence]
SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPV
QLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCDGLAPPQHLIR
VEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGM
NRRPILTIITLEDSSGNLLGRNSFEVHVCACPGRDRRREEENLRKKG
3D structure
PDB4ibw Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions.
ChainA
Resolution1.791 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A N239 S241 R248 H273 C275 A276 R280 R284 N143 S145 R152 H177 C179 A180 R184 R188
BS02 ZN A C176 H179 C238 C242 C83 H86 C142 C146
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ibw, PDBe:4ibw, PDBj:4ibw
PDBsum4ibw
PubMed23863845
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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