Structure of PDB 4ibc Chain A

Receptor sequence

>4ibcA (length=123) Species: 128952 (Ebola virus - Mayinga, Zaire, 1976) [Search protein sequence]

DISAKDLRNIMYDHLPGFGTAFHQLVQVICKLGKDSNSLDIIHAEFQASL
AEGDSPQCALIQITKRVPIFQDAAPPVIHIRSRGDIPRACQKSLRPVPPS
PKIDRGWVCVFQLQDGKTLGLKI

3D structure

PDB

4ibc In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity.

Chain

Resolution

1.745 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	12G	A	A221 Q241 Q244 V245 K248 K251 I295 D302	A4 Q24 Q27 V28 K31 K34 I78 D85	MOAD: Kd=1049uM PDBbind-CN: -logKd/Ki=2.98,Kd=1049uM

External links

PDB	RCSB:4ibc, PDBe:4ibc, PDBj:4ibc
PDBsum	4ibc
PubMed	24495995
UniProt	Q05127\|VP35_EBOZM Polymerase cofactor VP35 (Gene Name=VP35)