Structure of PDB 4ib4 Chain A

Receptor sequence
>4ib4A (length=375) Species: 562,9606 [Search protein sequence]
EEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLA
VADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIWHLC
AISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIET
NPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAAD
LEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKKDFRHGFDIL
VGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLQTISNEQRASKV
LGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGV
NPLVYTLFNKTFRDAFGRYITCNYR
3D structure
PDB4ib4 Structural features for functional selectivity at serotonin receptors.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ERM A D135 V136 S139 T140 V208 L209 T210 K211 M218 W337 F340 L347 V348 Q359 D88 V89 S92 T93 V158 L159 T160 K161 M168 W312 F315 L322 V323 Q334
BS02 CLR A G70 Y394 Y399 G23 Y369 Y374
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0042597 periplasmic space

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Biological Process
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Cellular Component
External links
PDB RCSB:4ib4, PDBe:4ib4, PDBj:4ib4
PDBsum4ib4
PubMed23519215
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P41595|5HT2B_HUMAN 5-hydroxytryptamine receptor 2B (Gene Name=HTR2B)

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