Structure of PDB 4i9z Chain A

Receptor sequence
>4i9zA (length=296) Species: 9606 (Homo sapiens) [Search protein sequence]
EETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNL
VQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKI
QNKLTDLEILALLIAALSHDLDHRGVNNSYLAQLYCHSIMEHHHFDQCLM
ILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRK
NQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDKNK
IPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAE
3D structure
PDB4i9z Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.
ChainA
Resolution2.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5BA A Y612 A779 V782 F786 M816 Q817 F820 Y78 A238 V241 F245 M254 Q255 F258 MOAD: ic50=18.2nM
PDBbind-CN: -logKd/Ki=7.74,IC50=18.2nM
BindingDB: IC50=18nM
BS02 ZN A H617 H653 D654 D764 H83 H119 D120 D223
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4i9z, PDBe:4i9z, PDBj:4i9z
PDBsum4i9z
PubMed23867165
UniProtO76074|PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase (Gene Name=PDE5A)

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