Structure of PDB 4i9t Chain A

Receptor sequence
>4i9tA (length=305) Species: 426430 (Staphylococcus aureus subsp. aureus str. Newman) [Search protein sequence]
SDSLSKSPENWMSKLDDGKHLTEINIPGSHDSGSFTLKDPVKSVWAKTQD
KDYLTQMKSGVRFFDIRGRASADNMISVHHGMVYLHHELGKFLDDAKYYL
SAYPNETIVMSMKKDYDSDSKVTKTFEEIFREYYYNNPQYQNLFYTGSNA
NPTLKETKGKIVLFNRMGGTYIKSGYGADTSGIQWADNATFETKINNGSL
NLKVQDEYKDYYDKKVEAVKNLLAKAKTDSNKDNVYVNFLSVASGGSAFN
STYNYASYINPEIAKTIKANGKARTGWLIVDYAGYTWPGYDDIVSEIIDS
NKLEH
3D structure
PDB4i9t The cation-pi box is a specific phosphatidylcholine membrane targeting motif.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H30 D31 R67 H80 D281
Catalytic site (residue number reindexed from 1) H30 D31 R67 H80 D281
Enzyme Commision number 4.6.1.13: phosphatidylinositol diacylglycerol-lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 INS A H30 R67 R166 D206 Y208 H30 R67 R166 D206 Y208
BS02 INS A Y285 T286 Y285 T286
Gene Ontology
Molecular Function
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4i9t, PDBe:4i9t, PDBj:4i9t
PDBsum4i9t
PubMed23576432
UniProtP45723|PLC_STAAE 1-phosphatidylinositol phosphodiesterase (Gene Name=plc)

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